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Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress
(AUG)
Several protective cellular mechanisms protect against the accumulation of reactive oxygen species (ROS) and the concomitant oxidative stress. Therefore, any reduction in glucose or fatty acid flux into cells leading to a ...
Muscle-Specific PPAR beta/delta Agonism May Provide Synergistic Benefits with Life Style Modifications
(2007)
Peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation ...
The Functions of PPARs in Aging and Longevity
(2007)
Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and ...