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dc.contributor.authorBousquet, J. and Pfaar, O. and Togias, A. and Schünemann, H.J. and Ansotegui, I. and Papadopoulos, N.G. and Tsiligianni, I. and Agache, I. and Anto, J.M. and Bachert, C. and Bedbrook, A. and Bergmann, K.-C. and Bosnic-Anticevich, S. and Bosse, I. and Brozek, J. and Calderon, M.A. and Canonica, G.W. and Caraballo, L. and Cardona, V. and Casale, T. and Cecchi, L. and Chu, D. and Costa, E. and Cruz, A.A. and Czarlewski, W. and Durham, S.R. and Du Toit, G. and Dykewicz, M. and Ebisawa, M. and Fauquert, J.L. and Fernandez-Rivas, M. and Fokkens, W.J. and Fonseca, J. and Fontaine, J.-F. and Gerth van Wijk, R. and Haahtela, T. and Halken, S. and Hellings, P.W. and Ierodiakonou, D. and Iinuma, T. and Ivancevich, J.C. and Jacobsen, L. and Jutel, M. and Kaidashev, I. and Khaitov, M. and Kalayci, O. and Kleine Tebbe, J. and Klimek, L. and Kowalski, M.L. and Kuna, P. and Kvedariene, V. and La Grutta, S. and Larenas-Linemann, D. and Lau, S. and Laune, D. and Le, L. and Lodrup Carlsen, K. and Lourenço, O. and Malling, H.-J. and Marien, G. and Menditto, E. and Mercier, G. and Mullol, J. and Muraro, A. and O’Hehir, R. and Okamoto, Y. and Pajno, G.B. and Park, H.-S. and Panzner, P. and Passalacqua, G. and Pham-Thi, N. and Roberts, G. and Pawankar, R. and Rolland, C. and Rosario, N. and Ryan, D. and Samolinski, B. and Sanchez-Borges, M. and Scadding, G. and Shamji, M.H. and Sheikh, A. and Sturm, G.J. and Todo Bom, A. and Toppila-Salmi, S. and Valentin-Rostan, M. and Valiulis, A. and Valovirta, E. and Ventura, M.-T. and Wahn, U. and Walker, S. and Wallace, D. and Waserman, S. and Yorgancioglu, A. and Zuberbier, T. and the ARIA Working Group
dc.date.accessioned2020-07-02T05:43:48Z
dc.date.available2020-07-02T05:43:48Z
dc.date.issued2019
dc.identifier.citationcited By 18
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068241434&doi=10.1111%2fall.13805&partnerID=40&md5=b9bf8ff7d91d9ef8a94a3003e7d72955
dc.identifier.urihttp://hdl.handle.net/20.500.12481/11384
dc.description.abstractAllergen immunotherapy (AIT) is a proven therapeutic option for the treatment of allergic rhinitis and/or asthma. Many guidelines or national practice guidelines have been produced but the evidence-based method varies, many are complex and none propose care pathways. This paper reviews care pathways for AIT using strict criteria and provides simple recommendations that can be used by all stakeholders including healthcare professionals. The decision to prescribe AIT for the patient should be individualized and based on the relevance of the allergens, the persistence of symptoms despite appropriate medications according to guidelines as well as the availability of good-quality and efficacious extracts. Allergen extracts cannot be regarded as generics. Immunotherapy is selected by specialists for stratified patients. There are no currently available validated biomarkers that can predict AIT success. In adolescents and adults, AIT should be reserved for patients with moderate/severe rhinitis or for those with moderate asthma who, despite appropriate pharmacotherapy and adherence, continue to exhibit exacerbations that appear to be related to allergen exposure, except in some specific cases. Immunotherapy may be even more advantageous in patients with multimorbidity. In children, AIT may prevent asthma onset in patients with rhinitis. mHealth tools are promising for the stratification and follow-up of patients. © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
dc.language.isoEnglish
dc.publisherBlackwell Publishing Ltd
dc.title2019 ARIA Care pathways for allergen immunotherapy
dc.typeReview
dc.contributor.departmentMACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France; INSERM U 1168, VIMA : Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, France; UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France; Euforea, Brussels, Belgium; Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany; Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany; Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States; Department of Health Research Methods, Evidence and Impact, Division of Immunology and Allergy, McMaster University, Hamilton, ON, Canada; Hospital Quirónsalud Bizkaia, Bilbao, Spain; Division of Infection, Immunity & Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou”, University of Athens, Athens, Greece; Department of Social Medicine, Faculty of Medicine, University of Crete and International Primary Care Respiratory Group, Crete, Greece; Faculty of Medicine, Transylvania University, Brasov, Romania; Centre for Research in Environmental Epidemiology (CREAL), ISGlobAL, Barcelona, Spain; IMIM (Hospital del Mar Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; ENT Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium; Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Comprehensive Allergy Centre, Member of GA2LEN, Humboldt-Uniersität zu Berlin, Berlin, Germany; Woolcock Institute of Medical Research, Woolcock Emphysema Centre and Local Health District, University of Sydney, Glebe, NSW, Australia; Allergist, La Rochelle, France; Imperial College London - National Heart and Lung Institute, Royal Brompton Hospital NHS, London, United Kingdom; Personalized Medicine Clinic Asthma & Allergy, Humanitas Research Hospital, Humanitas University, Milan, Italy; Institute for Immunological Research, University of Cartagena, Campus de Zaragocilla, Cartagena, Colombia; Foundation for the Development of Medical and Biological Sciences (Fundemeb), Cartagena, Colombia; Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network, Barcelona, Spain; Division of Allergy/Immunology, University of South Florida, Tampa, FL, United States; SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy; UCIBIO, REQUIMTE, Faculty of Pharmacy, and Competence Center on Active and Healthy Ageing of University of Porto (AgeUPNetWork), University of Porto, Porto, Portugal; ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil; WHO GARD Planning Group, Salvador, Brazil; Medical Consulting Czarlewski, Levallois, France; Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom; Guy's and st Thomas' NHS Trust, Kings College London, London, United Kingdom; Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, United States; Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan; Unité de pneumo-allergologie de l'enfant, pôle pédiatrique, CHU de Clermont-Ferrand-Estaing, Clermont-Ferrand, France; Allergy Department, IdISSC, Hospital Clinico San Carlos, Madrid, Spain; Department of Otorhinolaryngology, Academic Medical Centres, Amsterdam, Netherlands; CINTESIS, Center for Research in Health Technology and Information Systems, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Medida, Lda, Porto, Portugal; Allergist, Reims, France; Department of Internal Medicine, Section of Allergology, Erasmus MC, Rotterdam, Netherlands; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium; Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands; Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina; Allergy Learning and Consulting, Copenhagen, Denmark; Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland; Ukrainian Medical Stomatological Academy, Poltava, Ukraine; Institute of Immunology, Federal Medicobiological Agency, Laboratory of Molecular immunology, National Research Center, Moscow, Russian Federation; Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey; Allergy & Asthma Center Westend, Berlin, Germany; Center for Rhinology and Allergology, Wiesbaden, Germany; Department of Immunology and Allergy, Healthy Ageing Research Center, Medical University of Lodz, Lodz, Poland; Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland; Department of Pathology, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania; Faculty of Medicine, Institute of Clinical medicine, Clinic of Chest diseases and Allergology, Vilnius University, Vilnius, Lithuania; Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico; Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany; KYomed INNOV, Montpellier, France; University of Medicine and Pharmacy, Hochiminh City, Viet Nam; Department of Paediatrics, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Faculty of Health Sciences and CICS – UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal; Danish Allergy Centre, University of Copenhagen, Copenhagen, Denmark; CIRFF, Center of Pharmacoeconomics, University of Naples Federico II, Naples, Italy; Département de l’Information Médicale, Unité Médico-Economie, University Hospital, Montpellier, France; Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain; Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain; Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy; Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia; Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea; Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic; Allergy and Respiratory Diseases, Ospedale Policlino San Martino -University of Genoa, Genoa, Italy; Allergy Department, Pasteur Institute, Paris, France; David Hide Centre, St Mary's Hospital, Isle of Wight and University of Southampton, Southampton, United Kingdom; Department of Pediatrics, Nippon Medical School, Tokyo, Japan; Association Asthme et Allergie, Paris, France; Hospital de Clinicas, University of Parana, Parana, Brazil; Allergy and Respiratory Research Group, Medical School, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom; Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland; Allergy and Clinical Immunology Department, Centro Medico-Docente La Trinidad, Caracas, Venezuela; The Royal National TNE Hospital, University College London, London, United Kingdom; Immunomodulation and Tolerance Group, Imperial College London, London, United Kingdom; Allergy and Clinical Immunology, Imperial College London, London, United Kingdom; The Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom; Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria; Outpatient Allergy Clinic Reumannplatz, Vienna, Austria; Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Allergist, Montevideo, Uruguay; Clinic of Children's Diseases, Vilnius University Institute of Clinical Medicine, Vilnius, Lithuania; Department of Public Health, Institute of Health Sciences, Vilnius, Lithuania; European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium; Department of Lung Diseases and Clinical Immunology, Terveystalo Allergy Clinic, University of Turku, Turku, Finland; Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy; Pediatric Department, Charité, Berlin, Germany; Asthma UK, London, United Kingdom; Nova Southeastern University, Fort Lauderdale, FL, United States; Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada; Department of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
dc.identifier.DOI-ID10.1111/all.13805
dc.identifier.volume74
dc.identifier.pages2087-2102


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