Role of Bone Marrow-Derived Stem Cells in Wound Healing

Abstract

Wound healing is a complex process and some conditions such as diabetes is difficult to treat. In these conditions external cell support is required where mesenchymal stem cells can be functional and useful. One of the main sources for these cells is bone marrow. These cells can be separated from hematopoietic precursors by adhesive properties where they can proliferate, differentiate, and expand for clinical use. Their effect on wound healing depends on their interaction with other cells, in which their production of cytokine and growth factors play an important role during the healing process, especially for immune modulation. In this review, the effect of stem cells on wound healing with cell interaction, regulation of the matrix, and adhesion with secretion of cells will be discussed in order to understand the mechanisms used by these cells to achieve a better quality of life for the patient suffering from a non-healing wound. © 2018 John Wiley & Sons, Inc. All rights reserved.