Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study
Tarih
2018Yazar
Bousquet, J. and Devillier, P. and Anto, J.M. and Bewick, M. and Haahtela, T. and Arnavielhe, S. and Bedbrook, A. and Murray, R. and van Eerd, M. and Fonseca, J.A. and Morais Almeida, M. and Todo Bom, A. and Menditto, E. and Passalacqua, G. and Stellato, C. and Triggiani, M. and Ventura, M.T. and Vezzani, G. and Annesi-Maesano, I. and Bourret, R. and Bosse, I. and Caimmi, D. and Cartier, C. and Demoly, P. and Just, J. and Portejoie, F. and Siroux, V. and Viart, F. and Bergmann, K.C. and Keil, T. and Klimek, L. and Mösges, R. and Pfaar, O. and Shamai, S. and Zuberbier, T. and Mullol, J. and Valero, A. and Spranger, O. and Tomazic, P.V. and Kowalski, M.L. and Kuna, P. and Kupczyk, M. and Raciborski, F. and Samolinski, B. and Toppila-Salmi, S.K. and Valovirta, E. and Cruz, A.A. and Sarquis-Serpa, F. and da Silva, J. and Stelmach, R. and Larenas-Linnemann, D. and Rodriguez Gonzalez, M. and Burguete Cabañas, M.T. and Kvedariene, V. and Valiulis, A. and Chavannes, N.H. and Fokkens, W.J. and Ryan, D. and Sheikh, A. and Bachert, C. and Hellings, P.W. and VandenPlas, O. and Ballardini, N. and Kull, I. and Melén, E. and Westman, M. and Wickman, M. and Bindslev-Jensen, C. and Eller, E. and Bosnic-Anticevich, S. and O'Hehir, R.E. and Agache, I. and Bieber, T. and Casale, T. and Gemicioğlu, B. and Ivancevich, J.C. and De Vries, G. and Sorensen, M. and Yorgancioglu, A. and Laune, D. and MACVIA working group
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Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High—Asthma Low pattern. There were 1.7% days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity. © 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045929487&doi=10.1111%2fall.13448&partnerID=40&md5=226928e44e46ec47dc043259bad3e423http://hdl.handle.net/20.500.12481/12075
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- Scopus [2994]