dc.contributor.author | Yilmaz, S; Demirci, NY; Metintas, S; Zamani, A; Karadag, M; Guclu, OA; Kabalak, PA; Yilmaz, U; Ak, G; Kizilgoz, D; Ozturk, A; Yilmaz, U; Batum, O; Kavas, M; Serifoglu, I; Unsal, M; Komurcuoglu, BE; Cengiz, TI; Ulubay, G; Ozdemirel, TS; Ozyurek, BA; Kavurgaci, S; Alizoroglu, D; Celik, P; Erdogan, Y; In, E; Aksoy, A; Altin, S; Gunluoglu, G; Metintas, M | |
dc.date.accessioned | 2023-03-02T06:39:03Z | |
dc.date.available | 2023-03-02T06:39:03Z | |
dc.date.issued | MAR | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12481/14319 | |
dc.description.abstract | Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis. | |
dc.title | Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Study | |
dc.title.alternative | JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | |
dc.identifier.DOI-ID | 10.1097/JOM.0000000000002115 | |
dc.identifier.volume | 63 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 238 | |
dc.identifier.endpage | 243 | |
dc.identifier.issn/e-issn | 1076-2752 | |
dc.identifier.issn/e-issn | 1536-5948 | |