Investigation of effect of Vitamin D receptor, calcium-sensing receptor and ?-catenin on cutaneous squamous cell carcinoma [D vitamini reseptörü, kalsiyuma duyarlı reseptör ve ?-katenin'in skuamöz hücreli deri kanseri üzerine etkisinin araştırılması]

Abstract

Background: Cutaneous squamous cell carcinoma (cSCC) is a malignant and invasive tumor which is originated from epidermis with a high incidence among non-melanoma skin cancers. The aim of this study was to determine whether vitamin D receptor (VDR), calcium-sensing receptor (CaSR) and beta catenin (?-catenin) proteins have an effect on cSCC. Materials and methods: VDR, CaSR and ?-catenin proteins in tissue samples of cSCC and control group were analyzed by immunohistochemistry (IHC) and Western blotting (WB) method. IHC findings were statistically evaluated. Results: IHC staining density of VDR and ?-catenin were higher in cSCC tissue samples than control. The difference between IHC staining density of VDR and ?-catenin in the patient and the control groups were statistically significant (p = 0.021, p = 0.021, respectively), but not for CaSR (p = 0.237). While the VDR and ?-catenin staining rates obtained by the IHC method could be supported by WB results, the WB bands for CaSR could not be shown. Conclusion: The findings suggest that VDR and ?-catenin may have an effect on the disease. Further research is required to better understand the role of VDR and ?-catenin together on cSCC. © 2020 De Gruyter. All rights reserved.