Troponin-T Levels Can Predict Left Ventricle Remodeling in Chronic Hemodialysis Patients

Abstract

Objective: Cardiac troponin T (cTnT) is an important marker in patients with chronic renal failure (CRF) in the prediction of cardiovascular outcomes. We aimed to evaluate whether cTnT levels will provide further informationabout left ventricular geometric pattern in CRF as the result of patient’s volume status and efficacy of hemodialysis.Method: Sixty-one patients who underwent hemodialysis three times a week for more than 3 months (mean 19months) were included the study. One day before the mid-dialysis session, blood samples were taken from thepatients in the hemodialysis program and cTnT was studied. All patients underwent echocardiographic examination one day before the second hemodialysis session of the week by the same cardiologist.Results: When the groups were compared in terms of echocardiographic volume parameters; left atrium diameter,left ventricle (LV) mass, LV mass index were found to be higher in the cTnT positive group. The eccentric LV hypertrophy pattern was significantly more frequent in the cTnT-positive group (p:0.04).Conclusion: cTnT levels increase in hemodialysis patients with eccentric LV hypertrophy as the result of hypervolemia. In conclusion, cTnT could be used as a marker of LV geometric pattern and as a method for planning the treatment modalities in hemodialysis patients.