Toll-Like Receptor 2 Expression and Peripheral Blood CD4+/CD8+ T Cell Ratio in COPD
Date
2014Author
Gürol Şahin ULUTAŞ;AYLİN ÖZGEN ALPAYDIN;FATMA TANELİ;Cemile ÇETİNKAYA;Cevval ULMAN;YEŞİM GÜVENÇ DEMİRAĞCI;GÖNÜL DİNÇ HORASAN;Ayşın Şakar COŞKUN
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as well as the relationship of these cells with pulmonary functions in chronic obstructive pulmonary disease (COPD) patients.MATerIAL ANd MeTHods: Forty COPD patients and 40 healthy volunteers were included. Participants were analysed in four groups according to their smoking status. Peripheral blood CD4+ and CD8+ T cells and monocyte TLR-2 expression were measured by flow cytometry in the whole study population.resULTs: No significant difference was observed in TLR-2 expression, number of CD4+ and CD8+ T cells, and CD4+/CD8+ T cell ratio between the study groups. CD4+/CD8+ T cell ratio and FEV1/FVC were found to have a mild positive correlation (r=0.295, p=0.022). A mild negative correlation was observed between smoking intensity and CD4+/CD8+ T cell ratio (r=-0.274, p=0.034).CoNCLUsIoN: We demonstrated a mild correlation between pulmonary functions and peripheral blood CD4+/CD8+ T cell ratio. However, we did not find a significant difference in TLR-2 expression of CD14+ monocytes in patients with airway obstruction.
URI
https://app.trdizin.gov.tr/publication/paper/detail/TWpJM05EWTFOUT09http://hdl.handle.net/20.500.12481/2154
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