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dc.contributor.authorVildan TURAN FARAŞAT;TALAT ECEMİŞ;Yavuz DOĞAN;Aslı Gamze ŞENER;Gülfem TEREK ECE;Pınar ERBAY DÜNDAR;Tamer ŞANLIDAĞ
dc.date.accessioned2020-06-30T10:46:47Z
dc.date.available2020-06-30T10:46:47Z
dc.date.issued2019
dc.identifier.citation0
dc.identifier.urihttps://app.trdizin.gov.tr/publication/paper/detail/TXpJd01USTNOdz09
dc.identifier.urihttp://hdl.handle.net/20.500.12481/3393
dc.description.abstractObjectives: This study aims to evaluate the interpretation of the antinuclear antibody (ANA)-indirect immunofluorescence (IIF) test results based on the interpreter-related subjectivity and to examine the inter-center agreement rates with the performance of each laboratory. Patients and methods: The ANA-IIF testing was carried out in a total of 600 sera and evaluated by four laboratories. The inter-center agreement rates were detected. The same results given by the four centers were accepted as gold standard and the predictive values of each center were calculated. Results: The inter-center agreement was reported for ANA-IIF test results from 392 of 600 (65.3%) sera, while 154 of 392 results were positive. Four study centers reported 213 (35.5%), 222 (37.0%), 266 (44.3%), and 361 (60.2%) positive test results, respectively. In terms of the patterns, the highest and lowest positive predictive values were 72.3% and 42.7%, respectively, while the highest and lowest negative predictive values were 99.6% and 61.5%, respectively. The agreement for semi-quantitative evaluation at three levels of fluorescence intensity stated by four centers was detected in 100 sera at 87% 3(+), while the other two levels were 6% and 7%. The highest predictive value for the highest fluorescence intensity of 3(+) was found to be 71.9%. Conclusion: Significant differences may be observed among laboratories in terms of qualitative results, patterns, and semi-quantitative determination of the fluorescence intensity in the ANA-IIF testing, particularly at low fluorescence intensity levels and in those with speckled patterns. In case of any discrepancy between ANA-IIF test and clinical prediagnosis, the test should be repeated in another laboratory, if necessary.
dc.language.isoeng
dc.titleA Multicenter Analysis of Subjectivity of Indirect Immunofluorescence Test in Antinuclear Antibody Screening
dc.typeRESEARCH
dc.contributor.departmentMANİSA CELÂL BAYAR ÜNİVERSİTESİ;MANİSA CELÂL BAYAR ÜNİVERSİTESİ;DOKUZ EYLÜL ÜNİVERSİTESİ;Tanımlanmamış Kurum;Tanımlanmamış Kurum;MANİSA CELÂL BAYAR ÜNİVERSİTESİ;MANİSA CELÂL BAYAR ÜNİVERSİTESİ
dc.identifier.nameOfPublishedMaterialArchives of Rheumatology
dc.identifier.DOI-ID10.5606/ArchRheumatol.2019.7310
dc.identifier.volume34
dc.identifier.issue3
dc.identifier.startpage326
dc.identifier.endpage333
dc.identifier.issn/e-issn2148-5046;2618-6500


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