dc.contributor.author | Deliormanli, AM | |
dc.date.accessioned | 2020-07-01T08:19:10Z | |
dc.date.available | 2020-07-01T08:19:10Z | |
dc.date.issued | AUG | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12481/4309 | |
dc.description.abstract | Scaffold and mesenchymal stem cell-based cartilage tissue engineering offers a favorable way for the repair and regeneration of injured cartilage. In this study, poly (epsilon-caprolactone) PCL scaffolds with grid-like structure having periodic lattice was manufactured by robocasting method in the presence of graphene nanoplatelets for cartilage tissue engineering applications. For this purpose, a PCL solution (20wt%) containing pristine graphene nanopowders in the form of platelets was prepared as printing ink and it was dispensed through a nozzle at room temperature to an ethanol bath at 4 degrees C. The construction of porous scaffolds was made by a layer-by-layer assembly. Results revealed that graphene additions were not detrimental to deposition process and the structure of the resultant scaffolds. In vitro cell tests indicated that the prepared grid-like graphene/PCL composite scaffolds have good cytocompatibility and non-toxicity for mouse bone marrow mesenchymal stem cells. The stem cells attached and proliferated well on the scaffolds and they also demonstrated a chondrogenic differentiation in the absence of transforming growth factors. | |
dc.title | Direct Write Assembly of Graphene/Poly(epsilon-Caprolactone) Composite Scaffolds and Evaluation of Their Biological Performance Using Mouse Bone Marrow Mesenchymal Stem Cells | |
dc.title.alternative | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | |
dc.identifier.DOI-ID | 10.1007/s12010-019-02976-5 | |
dc.identifier.volume | 188 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 1117 | |
dc.identifier.endpage | 1133 | |
dc.identifier.issn/e-issn | 0273-2289 | |
dc.identifier.issn/e-issn | 1559-0291 | |