dc.contributor.author | Kilciksiz, S; Demirel, C; Ayhan, SE; Erdal, N; Gurgul, S; Tamer, L; Ayaz, L | |
dc.date.accessioned | 2020-07-01T08:44:32Z | |
dc.date.available | 2020-07-01T08:44:32Z | |
dc.date.issued | JAN-MAR | |
dc.date.issued | 2011 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12481/8301 | |
dc.description.abstract | Purpose: The present study was designed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) on radiation-induced nitrosative stress caused by gamma irradiation (single dose, 6 Gy) in rat liver Methods: The rats (n=40) were divided randomly and equally into 4 groups: Control (C), Radiation (R), R+NAC (received irradiation and 1,000 mg/kg of NAC) and R+WR-2721 (received irradiation and 200 mg/kg of WR-2721). Liver tissue of each animal was harvested and utilized for 3-nitrotyrosine (3-NT) detection using high-performance liquid chromatography-ultraviolet (HPLC-UV) system. Results: In the R rats, 3-NT levels significantly increased when compared to those of the C rats (p<0.05). There were no significant differences in the 3-NT levels among R+NAC and R+WR-2721 rats. Histologically examined liver tissue samples showed no obvious differences. Conclusion: The present study suggests that irradiation has a negative effect on the cellular proteins by enhancing 3-NT formation. The prophylactic use of NAC seems to reduce the nitrosative damage during radiotherapy. | |
dc.title | N-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver | |
dc.title.alternative | JOURNAL OF BUON | |
dc.identifier.volume | 16 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 154 | |
dc.identifier.endpage | 159 | |
dc.identifier.issn/e-issn | 1107-0625 | |
dc.identifier.issn/e-issn | 2241-6293 | |